The country has now more than 12 million confirmed infections, with more than 255,000 deaths, according to data compiled by Johns Hopkins University.
This is by far the highest death toll in the world.
About 187,000 new infections were recorded nationwide in the latest figures - released on Friday for the previous day - which is an all-time high.
Several states have imposed new mask mandates and restrictions to try to combat the rise, and in Texas the National Guard is being deployed to the city of El Paso to help with morgue operations there.
The Centers for Disease Control and Prevention (CDC) has also urged Americans to avoid travelling for the Thanksgiving holiday on 26 November to prevent increased transmissions.