The eight-hour broadcast saw more than 100 musicians performing in their living rooms, and broadcast on TV and streaming services around the globe.
Lady Gaga, who helped organise the concert, also performed.
Titled One World: Together At Home, the concert was organised by the Global Citizen movement and the World Health Organization (WHO).
It began with a montage of people under lockdown applauding the efforts of healthcare workers around the world - from France, Spain, the UK, the US and elsewhere.
Proceeds generated from the concert will go to the Covid-19 Solidarity Response Fund for the WHO, but Lady Gaga made clear the show was not a fundraising telethon and would focus on entertainment and messages of solidarity.
Watch the show from below :